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Trevor Howe



Trevor Howe

Trevor Howe

Director, External Innovation

Jan-Cil UK

Why I'm a JPAL

Enthusiasm for transformational technology in healthcare.


Trevor is a Janssen Fellow, Director and Head of Translational Genomics for Johnson & Johnson Innovation. He is responsible for identifying and validating drug targets or pathways from human genetic signatures though internal and external collaborations.

He joined Janssen in 2003 where he formed the Molecular Informatics group to focus on structural biology, biophysics & computational methods for ligand identification and optimisation in all phases of pre-clinical drug discovery process.

Prior to Trevor’s current Johnson & Johnson/Janssen career, he headed the worldwide Computational Chemistry Council for Novartis from 1997 – 2003. He also led several immunology projects which resulted in successful clinical candidates for the respiratory disease therapeutic area. From 1990 – 1997 Trevor worked for Lilly establishing their computational chemistry department in the UK. He was simultaneously a visiting researcher at the University of Oxford with Prof Graham Richards.

Trevor’s first degree was in Chemistry at the University of Exeter which was followed by a PhD at the University of East Anglia on small molecule conformation. From 1988 – 1990 he was a postdoctoral researcher at SUNY, Buffalo, USA studying glucosidase inhibition for applications to HIV.

Trevor serves on several UK Research Council scientific advisory bodies and boards and on the Structural Genomics Consortium (SGC) Board in Oxford and Toronto. He has been a visiting Industrial Fellow at Bristol University and is Board member and co-founder of Phenotypic Discovery Initiative (http://npsc.ac.uk/consortia) which he established with the Universities of Oxford, Edinburgh and Dundee. In 2019 he was the J&J scientific lead for a consortium which is now executing the world’s biggest whole genome sequencing project on the 500,00 samples in the UK BioBank


"So it goes"

Fun fact:

I can wiggle my ears