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Zhicai Shi



Zhicai Shi

Zhicai Shi

Senior Scientific Director, Discovery Chemistry

Janssen R&D US

Why I'm a JPAL

Innovation is a critical component of drug discovery. I enjoy interacting with innovators in drug discovery space and aspire to accelerate the invention of medicines through innovations.


Zhicai Shi is a Senior Scientific Director, Discovery Chemistry at Janssen Discovery Sciences. Zhicai is currently leading the effort to identify, develop, implement and apply innovative chemistry capabilities to accelerate Janssen discovery programs. Zhicai has extensive drug discovery experiences, including leading discovery projects, chemistry capabilities and external research, at Janssen, Merck and Lexicon Pharmaceuticals. At Lexicon, Zhicai and his team discovered a first-in-class Tryptophan Hydroxylase inhibitor Telotristat, which was approved by FDA in 2017 for the treatment of Carcinoid Syndrome. Prior to Janssen, Zhicai led a team of scientists which developed and applied innovative chemistry capabilities such as parallel medicinal chemistry, high throughput purification, high throughput experimentation and DNA-encoded library technology in discovery chemistry at Merck.


Technology is unlocking the innate compassion we have for our fellow human beings.

Fun fact:

I co-lead a youth program in my spare time.