Cyclica Inc.

Cyclica Inc. has developed, validated, patented and commercialized Ligand Express™, a cloud-based Software-as-a-Service platform that screens small-molecule drugs against repositories of structurally-characterized proteins or ‘proteomes’ to determine polypharmacological profiles. Accordingly, Ligand Express™ identifies significant protein targets using an innovative structure-based and drug-centric technology, leverages artificial intelligence to determine the drug’s effect on these targets, and visualizes the predicted drug-protein interactome using bioinformatics and systems biology. The platform provides a unique panoramic view of a small-molecule, by identifying on- and off-target interactions that may be expected, as well as those that are unanticipated. By understanding how a small-molecule drug will interact with all proteins in the body, Ligand Express™ augments scientific investigation by elucidating mechanism-of-action, prioritizing lead candidates, understanding side effects, as well as determining new uses for existing drugs. For more information please visit:

Focus area
Platform / research tool
Commencement date
09/11/2017