Artificial Intelligence for Drug Discovery

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12/12/2017 16:45 12/12/2017 21:00 America/Toronto Artificial Intelligence for Drug Discovery JLABS @ Toronto , 661 University Ave , Toronto , ON M5G 1M1 JLABS @ Toronto false DD/MM/YYYY

Artificial Intelligence for Drug Discovery

JLABS @ Toronto , 661 University Ave , Toronto , ON M5G 1M1

December 12, 2017 from 16:45 PM to 21:00 PM (EDT)

$10 - $35

Artificial intelligence (AI) poses unlimited opportunity for us to make a transformative impact on patients. Whether it be through new drug combinations, improved medical diagnostics, better accuracy in personalized medicine, or many other benefits - AI could save scientists valuable research time and bring new treatments to patients more quickly.

For this reason, Johnson & Johnson Innovation and Janssen Research & Development launched the Artificial Intelligence for Drug Discovery QuickFire Challenge. Johnson & Johnson Innovation will award up to $100,000 in grants, one year of JLABS residency & mentorship to the individuals or teams who submit the best ideas, technologies, or solutions that are using artificial intelligence to advance healthcare.

On December 12th, join us at JLABS @ Toronto as we hear from the finalists of this challenge and choose the winner(s) with the help of a judging panel & the attendees.

During deliberations attendees will hear from an esteemed panel of experts in the artificial intelligence/machine learning field, with speakers from Janssen R&D, Real Ventures, Vector Institute, University of Toronto & Cyclica Inc.

3:45pm | Registration Opens & Networking
4:00pm | Opening Remarks
4:15pm | Presentations from Finalists
5:45pm | Bio Break
6:00pm | Panel Discussion
7:00pm | Networking
7:30pm | Announcement of Winners
8:00pm | Program Close

JS Cournoyer | General Partner, Real Ventures read bio»
Anna Goldenberg | Scientist, The Hospital for Sick Children; Assistant Professor, University of Toronto Department of Computer Science read bio»
Naheed Kurji | President & CEO, Cyclica Inc. read bio»
Jeffrey J. Headd | Senior Data Scientist, Janssen Research & Development, LLC read bio»

$25 | General Public

JLABS @ Toronto
661 University Ave, Suite 1300
Toronto, Ontario

A2A Pharmaceuticals
A2A Pharmaceuticals cuts the time and cost of identifying drug-like lead compounds against difficult-to-drug targets using an innovative de-novo fragment-based discovery approach. Its proprietary SCULPT methodology leverages structural, biochemical, mutagenesis and ligand-binding data to design large virtual libraries of pre-optimized molecules with spatial and chemical features specific for each target. An iterative combination of docking and supervised machine learning guides library optimization and selects the best candidates for synthesis and pharmacological validation.

Envisagenics is a spin out of Cold Spring Harbor Laboratory leveraging the therapeutic potential of aberrant splicing through artificial intelligence (AI). Many human diseases are triggered by aberrant splicing events that can be targeted and corrected by small molecules or antisense drugs. Envisagenics SpliceCoreTM platform combines transcriptomic mapping and machine learning to prioritize therapeutic candidates from several terabytes of RNA-seq data. Envisagenics competitive advantage is its experimentally validated product and innovative exon-centric approach to target exons instead of genes, opening up new therapeutic opportunities.

EnBiotix, Inc.
EnBiotix, Inc. is a bioengineering company with a focus on anti-infectives and innovative platforms in systems biology and synthetic biology. These technologies, initially developed by EnBiotix co-founder and SAB Chair Professor James J. Collins (MIT, Broad, Harvard Wyss), are transformational with respect to time, cost, efficiencies, and quality of results. Our systems biology MINE Platform is a machine learning approach that allows for rapid identification of the mechanism of action (“MOA”) of a perturbation, identification of biological targets for therapeutic intervention, and precise patient stratification.

Bringing a single new drug to the market costs $2.6bn, often delivering an intervention that barely differs from those already in the market. Projections into the future are not promising, with an expected 50% drop in R&D output every nine years.
At GTN we are searching the astronomically large space of drug-like molecules with our unique patented technology, Generative Tensorial Networks. Our software combines and builds upon techniques from machine learning and quantum physics to simulate, filter and search for molecules, halving development costs and discovering molecules entirely hidden from view.

Phenomic AI
Phenomic AI is building an AI powered drug discovery platform that unifies target based and phenotypic approaches with computational drug design and optimization. By integrating insights extracted from high-throughput imaging screens with deep representations of molecular structure, our platform is able to efficiently map and explore chemical and phenotypic space, enabling us to rapidly discover novel compounds with desirable therapeutic and pharmacological properties.

Without a reliable, simulated model of biology, years of lab work and even longer clinical trials are needed to make sure a drug helps patients. The question we asked ourselves a decade ago was - can we move trial and error out of labs and trials onto the computer? The result is a Simulated Cell that turns static, sequenced data from patients and lab models into live, simulated tumors. Allowing researchers to run millions of simulated experiments in the time it would take them to run a biological one, we find the best ways to fight against cancer. Insights gained can generate new ideas or confirm hypotheses of rational combinations, predictive molecular biomarkers and resistance mechanisms (both intrinsic and acquired).

Tracery is clinical stage ocular imaging and health tech company harnessing structured and unstructured data, OMICS, and large data analytics, for the co-development of new diagnostic tools and individualized therapeutic strategies globally through the cloud, advancing therapies for retinal disease.

Speaker Biography:
JS Cournoyer | General Partner, Real Ventures
JS is an entrepreneur at heart. When he is not taking care of his five children, he chooses to dedicate his life helping passionate entrepreneurs trying to change the world realize their vision and succeed in life and in business. JS likes to work with entrepreneurs who use A.I and blockchain technologies to improve human creativity, communication and happiness or to transform the pillars of our society (health, education, food, energy, government, finance, work, transportation).

Anna Goldenberg | Scientist, The Hospital for Sick Children; Assistant Professor, University of Toronto Department of Computer Science
Dr Goldenberg is a Scientist in Genetics and Genome Biology program at the SickKids Research Institute and an Assistant Professor in the Department of Computer Science at the University of Toronto. She is also a fellow of the Canadian Institute for Advanced Research and a member of Vector Institute. Dr Goldenberg’s lab develops machine learning approaches that efficiently combine many types of patient measurements to refine diagnosis, improve prognosis and personalise drug response prediction in the context of complex human diseases. Dr Goldenberg was recently awarded an Early Researcher Award from the Ministry of Research and Innovation.

Naheed Kurji | President & CEO, Cyclica Inc.
Naheed is President and CEO of Cyclica, where he leads the team in delivering the next step in cloud-based drug discovery. Naheed focuses on corporate and business growth strategies to ensure the company is set up for success. Naheed received his MBA from the University of Toronto, Rotman School of Management. Prior to joining Cyclica, Naheed worked as an Associate Director at Bank of Montreal in Calgary where he was integral in multiple cross-border sponsor coverage deals.

Jeffrey J. Headd | Senior Data Scientist, Janssen Research & Development, LLC
Jeff is a member of the Data Sciences IT team at Janssen Research & Development, LLC. Working out of the Spring House, PA, campus, Jeff and his colleagues collaborate with company-wide business partners to address data-driven questions spanning the pharmaceutical pipeline. As a member of this multidisciplinary team, he applies expertise in data integration, algorithmic development, and modern analytical methods to leverage internal and external data sources.
Jeff holds a Ph.D. in Computational Biology and Bioinformatics from Duke University. Prior to joining Janssen R&D, he worked in methods development for macromolecular crystallography as a member of the Phenix team at both Duke University and Lawrence Berkeley National Lab.

JLABS @ Toronto

About Johnson & Johnson Innovation, JLABS Johnson & Johnson Innovation, JLABS (JLABS) is a global network of open innovation ecosystems, enabling and empowering innovators to create and accelerate the delivery of life-saving, life-enhancing health and wellness solutions to patients around the world. JLABS achieves this by providing the optimal environment for emerging companies to catalyze growth and optimize their research and development by opening them to vital industry connections, delivering entrepreneurial programs and providing a capital-efficient, flexible platform where they can transform the scientific discoveries of today into the breakthrough healthcare solutions of tomorrow. At JLABS we value great ideas and are passionate about removing obstacles to success to help innovators unleash the potential of their early scientific discoveries. JLABS is a no-strings-attached model, which means entrepreneurs are free to develop their science while holding on to their intellectual property. JLABS is open to entrepreneurs across a broad healthcare spectrum including pharmaceutical, medical device, consumer and healthtech sectors. The JLABS flagship opened in 2012 in San Diego at Janssen's West Coast Research Center, and since then has grown to ten global locations including the Bay Area, Boston & Lowell, MA, Houston, Toronto, Beerse (Belgium), with New York City, opening in June 2018, and Shanghai in 2019. For more information please visit or follow @JLABS. About Johnson & Johnson Innovation Johnson & Johnson Innovation focuses on accelerating all stages of innovation worldwide and forming collaborations between entrepreneurs and Johnson & Johnson's global healthcare businesses. Johnson & Johnson Innovation provides scientists, entrepreneurs and emerging companies with one-stop access to science and technology experts who can facilitate collaborations across the pharmaceutical, medical device and consumer companies of Johnson & Johnson. Under the Johnson & Johnson Innovation umbrella of businesses, we connect with innovators through our regional Innovation Centers, Johnson & Johnson Innovation | JLABS, Johnson & Johnson Innovation - JJDC, and our Business Development teams to create customized deals and novel collaborations that speed development of innovations to solve unmet needs in patients. For more information please visit or follow @JNJInnovation.

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